https://www.genengnews.com/news/covid-19-infection-model-described-in-cynomolgus-macaques/
The discovery of COVID-19 treatments is urgently needed. As part of that process, so too are appropriate animal models to test them. However, which animal(s) can be the most useful in this scientific endeavor remains a question. A group from the Netherlands sought to address this question. They infected young and aged cynomolgus macaques with a clinical isolate of SARS-CoV-2. The pathogenesis of SARS-CoV infection had been previously studied in this nonhuman primate model.
Not only did they characterize the infection of SARS-CoV-2, they also compared that infection with that of MERS-CoV, and results with historical reports of infections by SARS-CoV. After comparing how the coronavirus infections develop in cynomolgus macaques, the researchers reported that SARS-CoV-2 gives the animals a mild COVID-19-like disease and suggest that these animals are a promising model for testing COVID-19 therapeutics. “This study provides a novel infection model,” the authors wrote, “which will be critical in the evaluation and licensure of preventive and therapeutic strategies against SARS-CoV-2 infection for use in humans.”
荷蘭的團隊利用馬來猴建立了新一種的非人靈長類實驗動物模式。研究人員在感染冠狀病毒的馬來獼猴身上觀察到人類相似的臨床呼吸症況，這樣子的動物模式可以更有效地來模擬病毒在人體造成的症狀，對於不論是疫苗或是解藥上的開法更能夠有效的反應實際成效。
操作感染疾病動物模式，除了需要專業的團隊外，也需要有合適的設備來進行實驗。若機構單位對於感染性的動物模式、飼養環境及相關設備需要諮詢的需求，歡迎與本公司聯絡。